PRELIMINARY PROGRAM - May be subject to change.

Working titles shown.  Final titles will be announced.

Educational Sessions

     NEW this year!  Designed to provide opportunities for clinicians and investigators who may be lacking

     access to these important aspects of breast cancer treatment and research.

     Emerging Targets

Novel Anti-HER 2 strategies in the therapy of breast cancer

José Baselga, MD, Vall d'Hebron University Hospital

Disrupting IGF signaling in breast cancer as a therapeutic strategy

Douglas Yee, MD, University of Minnesota

     Signal Transduction Pathways Controlling Proliferation and Death in Breast Cancer

TBA

Carlos Arteaga, MD, Vanderbilt-Ingram Cancer Center

Killing cancer cells via the mitochondrial apoptotic pathway

Anthony Letai, MD, PhD, Dana-Farber Cancer Institute

     Clinical Trials 101

TBA

Susan Hilsenbeck, PhD, Baylor College of Medicine

Cancer Clinical trials in the 21st century: the need for a "paradigm shift" in their design, conduct and support

Martine Piccart, MD, PhD, Jules Bordet Institute

     Pathobiology

TBA

Andrea Richardson, MD, PhD, Dana-Farber Cancer Insitute

TBA

Basic Science Panel Discussions

     Breast Cancer Stem Cells: To believe or not to believe?

Moderator: Jeffrey Rosen, MD, PhD, Baylor College of Medicine

TBA

Max Wicha, MD, University of Michigan

Breast cancer stem cells: in search of definitions, markers, and clinical relevance

Kornelia Polyak, MD, PhD, Dana-Farber Cancer Institute

    Genetic changes in the stroma – yes or no?

Moderator: Charlotte Kuperwasser, PhD, Tufts University

TBA

Charis Eng, MD, PhD, Case Western Reserve University School of Medicine

Changes in the tumor microenvironment: genetic or epigenetic?

Kornelia Polyak, MD, PhD, Dana-Farber Cancer Institute

Case Discussions

The William L. McGuire Memorial Lectureship

    What is Cancer? How Modern Molecular Science is Challenging Traditional Views

    Larry Norton, MD, Memorial Sloan-Kettering Cancer Center

AACR Senior Investigator Award

     Micro RNA and Metastases

     Joan Massague, PhD, Memorial Sloan-Kettering Cancer Center

Susan G. Komen for the Cure-AACR Outstanding Investigator Award for Breast Cancer Research

     Nominations are now open!  Nomination Deadline: Thursday, July 10, 2008

Plenary Lectures

     Circulating Tumor Cells

     Klaus Pantel, MD, University Medical Center Hamburg-Eppendorf Institute of Tumor Biology

     Signal Transduction and Endocrine Therapy Combination

     Stephen Johnston, MA, PhD, FRCP, Royal Marsden NHS Foundation Trust and Institute of Cancer

     Research

     What is the role of MRI in the newly diagnosed breast cancer patient?

     Monica Morrow, MD, FACS, Memorial Sloan-Kettering Cancer Center

Mini-Symposia

     Risk Assessment and Risk Reduction Strategies

Moderators:

J. Dirk Iglehart, MD, Dana-Farber Cancer Institute

Lynn C. Hartmann, MD, Mayo Clinic

Risk and risk reduction

Lynn C. Hartmann, MD, Mayo Clinic

Trends in the use of prophylactic surgery

Todd M. Tuttle, MD, MPH, University of Minnesota

Diagnosis and prevention of breast cancer in women at high-risk

William C. Wood, MD, Emory University School of Medicine

Deployment of risk assessment tools

Joann G. Elmore, MD, MPH, University of Washington

     Molecular Profiling for Guiding Therapeutic Decisions

Moderators:

Suzanne A.W. Fuqua, PhD, Baylor College of Medicine

Laura van't Veer, PhD, Netherlands Cancer Institute

RNA

Laura van't Veer, PhD, Netherlands Cancer Institute

Systems approach to personalized molecular medicine

Gordon B. Mills, MD, PhD, UT, MD Anderson Cancer Center

Susceptibility & clinical outcome

Professor Doug Easton, PhD, FMedSci, University of Cambridge

     New Data on Imaging

Moderators:

Judy Garber, MD, Dana-Farber Cancer Institute

David Mankoff, MD, PhD, University of Washington

Overview of modalities and PET imaging

David Mankoff, MD, PhD, University of Washington

Breast ultrasound

Wendie A. Berg, MD, PhD, FACR, Johns Hopkins Breast Center

Breast MRI

Mitchell D. Schnall, MD, PhD, University of Pennsylvania

Molecular imaging

David R. Piwnica-Worms, MD, PhD, Washington University